Consumables of different type can boost something twice and not more than that at the same time. Means if you think you've finished everything possible somewhere, you most probably didn't because why not irritate the player. It gets even worse, a certain (not very useful, but fun) perk is locked on a weekday and lottery draw happens only at sundays for example. Some stuff happens only at night, some only during day. The game uses classic design crime to lock quests and NPCs based on time cycle. I wish the game had more c&c instead of different difficulty nonsense. Hostiles remain challenging the same way. Lesser the difficulty, better the rewards.

Difficulty is the same whichever you pick. Anyway, to avoid sidekicks die in most stupid ways possible, tank with MC as much as you can.

Your crewmembers don't know how to use healing items properly plus they toss grenades randomly, means throwable AoE stuff and stims keep in your inventory/belt. Not only hostiles, but your crew is not careful and friendly fire is imminent. I did and eventually reached the point of pretty much tanking/healing MC during the fight all the bloody time and dealing no damage to anyone. Melee or unarmed is utterly useless in this game. Perks you get within the game, where to go for good stuff and other tips will go into another post. Except stuff I learned in my own game, I've also read numerous threads and guides (not spoilerish walkthroughs!) so won't link them all.

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